Intraoperative hypotension
Conditions
Interventions
experimental group:During the operation, alfentanil combined with remimazolam was used for anesthesia and sedation.
control group:During the operation, alfentanil combined with propofol was used for anesthesia and sedation.
Sponsors
People's Hospital of Leshan
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients who undergo elective painless linear ultrasonic gastroscopy examination; 2.Age range: 18 - 80 years old. Gender: No restrictions. 3.Body Mass Index (BMI): 18.5 - 28 kg/m^2; 4.American Society of Anesthesiologists Classification (ASA): I - III grades; 5.The operation time is within 1 hour. 6.The subjects voluntarily participated in this trial and signed the informed consent form for this trial.
Exclusion criteria
Exclusion criteria: 1.The subjects explicitly refused to participate in this study. 2.Those with a previous history of allergic reactions to opioid drugs, benzodiazepines, propofol, flumazenil, or naloxone excipients; 3.Use beta-blockers, anti-anxiety drugs, and antidepressants; 4.Those suspected of abusing narcotic painkillers or sedatives, as well as alcoholics; 5.Electrocardiogram indication: Heart rate less than 50 beats per minute or more than 100 beats per minute, or presence of severe arrhythmia; 6.A history of acute respiratory infection within the past two weeks that has not been cured; 7.Those with a history of severe heart, brain, lung, liver, kidney or metabolic diseases, as well as those with neurological and muscular disorders (such as myasthenia gravis), or mental illnesses; 8.Patients with preoperative hypertension had a systolic blood pressure greater than 180 mmHg and/or a diastolic blood pressure greater than 110 mmHg, or patients with hypotension had a blood pressure lower than 90/60 mmHg. 9.Those who have a history of abnormal anesthesia recovery after previous surgeries; 10.Predict those who may or have had difficulty in breathing, such as those classified as grade ?-? according to the modified Mallory classification; 11.Pregnant or lactating women, as well as women with a planned pregnancy within the next 3 months; 12.Other researchers considered other participants who were not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time from awakening to leaving the post-anesthesia care unit (PACU);awakening time;Physical movement;The proportion of successful operations; | — |
Countries
China
Contacts
Public ContactLiang Jin
People's Hospital of Leshan
Outcome results
None listed