?Zoster-associated neuralgia
Conditions
Interventions
Short-term Spinal Cord Stimulation (st-SCS) Treatment Group:Administer short-term spinal cord stimulation to patients with herpes zoster-associated neuralgia. Operation: Implant a temporary spinal cor
simultaneously provide basic drug treatment (pregabalin, initial dose 75mg twice daily, adjusted according to pain tolerance).
Conventional Drug Combined with Stepwise Invasive Treatment Group:Administer conventional drug treatment combined with stepwise invasive treatment when necessary to patients with herpes zoster-associa
2. Nerve block (Step 1): If NRS score decreases by =5 after 2 nerve block treatments, perform CT-guided dorsal root ganglion pulsed radiofrequency treatment with parameters: temperature 42?, duration
Sponsors
?The First Affiliated Hospital of Anhui Medical University??
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Meets the diagnostic criteria for ZAN (disease duration <=3 months, including acute and subacute stages); 2.No history of opioid abuse; 3.Able to understand and complete self-assessment scales; 4.Voluntarily participates and signs informed consent.
Exclusion criteria
Exclusion criteria: 1.Pain-related sensory loss in the target area; 2.Spinal lesions or deformities precluding electrode implantation; 3.Presence of tumors or tuberculosis at puncture sites or within the spinal canal; 4.Active systemic infection or local infection at puncture site; 5.Severe coagulation dysfunction or ongoing anticoagulant therapy; 6.Major organ dysfunction or terminal cancer rendering surgery intolerable; 7.Intellectual or psychiatric disorders impairing comprehension of self-assessment scales; 8.Pregnancy/lactation or concurrent hormone therapy; 9.Allergy to local anesthetics/therapeutic agents or coexistence of other neuropathic pain conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain relief response rate (>=50% reduction in NRS score at 4 weeks post-treatment);Incidence of postherpetic neuralgia (PHN); | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain intensity (NRS score);Quality of life (SF-36 questionnaire score);Analgesic medication use (mean daily dose of pregabalin); | — |
Countries
China
Contacts
Public ContactKe Penghui
?The First Affiliated Hospital of Anhui Medical University??
Outcome results
None listed