None
Conditions
Interventions
Group of Dexmedetomidine nasal spray :Nasal inhalation of dexmedetomidine nasal spray
Group of sodium chloride:Nasal inhalation of an equal volume of physiological saline spray
Sponsors
Weifang People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.ASA class I-III 2.Aged 18-65 years 3.Require the use of sufentanil for endotracheal intubation under general anesthesia induction 4.Voluntarily signed informed consent form
Exclusion criteria
Exclusion criteria: 1.Drug allergy 2.Sinoatrial bradycardia 3.Severe neurological, respiratory, or cardiovascular diseases 4.Anesthetic drug dependence 5.Severe liver or kidney dysfunction 6.Pregnancy, lactation, and parturition surgery 7.Patients with upper respiratory tract infections within 2 weeks or conditions that may lead to spontaneous coughing 8.Patients deemed unsuitable for nasal administration by the investigator (e.g., severe rhinitis, nasal polyps, nasal deformities, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of coughing after sufentanil injection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients with coughs of different severity grades;Systolic blood pressure;Diastolic blood pressure;Heart rate;Pulse oxygen saturation;Other adverse effects related to dexmedetomidine nasal spray and sufentanil; | — |
Countries
China
Contacts
Public ContactShaojie Zhang
Weifang People’s Hospital
Outcome results
None listed