heart disease
Conditions
Interventions
Low Remimazolam Group:General anesthesia was induced with remimazolam at 0.2 mg/kg.
Medium Remimazolam Group:General anesthesia was induced with remimazolam at 0.3mg/kg.
High Remimazolam Group:General anesthesia was induced with remimazolam at 0.4mg/kg.
Etomidate Group:General anesthesia was induced with etomidate at 0.3mg/kg.
Sponsors
The First People's Hospital of Changzhou
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients aged 18–80 years scheduled for general anesthesia; 2.With confirmed cardiac comorbidities (coronary artery disease, NYHA class I–II heart failure, chronic atrial fibrillation, infrequent ventricular premature beats, valvular heart disease, etc.); 3.ASA physical status class II–IV.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of allergy to the study drug(s) used in this project; 2.Patients with psychiatric disorders, severe hypertension, diabetes mellitus, pheochromocytoma, uncontrolled hyperthyroidism, or other relevant diseases; 3.Patients in the acute phase of a cardiac attack.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stroke Volume;Cardiac Output;Systemic Vascular Resistance;Left Ventricular Stroke Work;Mean Arterial Pressure;Heart Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time;Post-Anesthesia Care Unit Stay Time;The incidence of adverse cardiovascular events;The incidence of Postoperative Delirium;cTn;BNP;The incidence of postoperative nausea and vomiting (PONV); | — |
Countries
China
Contacts
Public ContactYuan Wen
The First People's Hospital of Changzhou
Outcome results
None listed