Sepsis and septic shock
Conditions
Interventions
The control group :Conventional double-pump continuous pumping method (automatic 2-step continuous pumping)
Intervention group: Intelligent medium continuous pumping method (intelligent multi-step 4 or 8-step continuous pumping)
Sponsors
Zhongda Hospital Affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult (>= 18 years old) sepsis patients admitted to the ICU during the study period (sepsis diagnosis standard is sepsis 3.0); 2. Continuous intravenous infusion of norepinephrine during ICU with a dose greater than 15ug/min;
Exclusion criteria
Exclusion criteria: 1. Severe hemodynamic instability (increase of vasoactive drug dose or MAP 100ug/min); 2. Severe other organ dysfunction is expected to result in short-term death (7 days) or palliative treatment; 3. Late stage solid organ or hematological system tumors with an estimated survival time of<30 days; 4. Pregnancy; 5. Participate in other clinical studies within 30 days; 6. Unsigned informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of mean arterial pressure (MAP) decrease >20%; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure (SBP) level;Diastolic blood pressure (DBP) level;Heart rate (HR) level;Mean arterial pressure (MAP) level;Central venous pressure (CVP) level;Infusion pressure of syringe pump;Number of organ dysfunction (single item >=3 points in SOFA score);Need for mechanical ventilation;Total duration of mechanical ventilation;Use of corticosteroids;Use of neuromuscular blocking agents;ICU length of stay;ICU mortality rate;In-hospital mortality rate;Mechanical ventilation rate;28-day ventilator-free days;28-day ICU-free days;28-day mortality rate;Number of organ dysfunction; | — |
Countries
China
Contacts
Public ContactLi Xiaoqing
Zhongda Hospital Affiliated to Southeast University
Outcome results
None listed