Hyperkalemia
Conditions
Interventions
Experimental Group:Blood potassium (5.0-6.0mmol/L), 5g of sodium zirconium cyclosilicate orally administered daily on non-dialysis days
Blood potassium (>6.0mmol/L), 10g of sodium zirconium cyclosilicate orally per day on non-dialysis days
After the blood potassium control target was reached (4.0-5.0mmol/L), 2.5g of SZC was orally administered daily for maintenance on non-dialysis days. If the blood potassium level is less than 4.0mmol/
Control group:Hemodialysis (HD) was performed using dialysate with a potassium ion concentration of 2.0mmol/L three times a week. The Single-Pool urea clearance index (single-pool Kt/V, spKt/V) reache
Sponsors
Lin'an District First People's Hospital of Hangzhou (Affiliated Lin'an People's Hospital of Hangzhou Medical College)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-80 years; 2. Eligible for long-term hemodialysis, dialysis duration of more than 3 months; 3. Meet the diagnostic criteria for hyperkalemia (using pre-dialysis blood samples, with results showing serum potassium >5.0 mmol/L on two occasions, and the last serum potassium >5.0 mmol/L); 4. Randomly include patients who are routinely using RAASi medications (including angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers).
Exclusion criteria
Exclusion criteria: 1. Patients with acute renal failure undergoing hemodialysis; 2. Hyperkalemia caused by potassium supplements and other potassium-sparing drugs; 3. Patients with severe primary diseases involving the heart, brain, liver, or hematopoietic system; patients with a history of or newly diagnosed tumors; 4. Patients with a history of mental disorders; 5. Patients who do not agree to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood potassium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood calcium;Blood magnesium;Serum albumin;Hemoglobin;Muscle mass; | — |
Countries
China
Contacts
Public ContactYan Jiang
Lin'an District First People's Hospital of Hangzhou (Affiliated Lin'an People's Hospital of Hangzhou Medical College)
Outcome results
None listed