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Diagnostic Value of AI-Assisted Non-Contrast CT in Acute Chest Pain Patients Without Clinical Suspicion of Acute Aortic Syndrome: A Multicenter, Prospective Observational Study

Diagnostic Value of AI-Assisted Non-Contrast CT in Acute Chest Pain Patients Without Clinical Suspicion of Acute Aortic Syndrome: A Multicenter, Prospective Observational Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600119027
Enrollment
Unknown
Registered
2026-02-14
Start date
2026-02-16
Completion date
Unknown
Last updated
2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Aortic Syndromes

Interventions

Gold Standard:CTA (Computed Tomography Angiography), TEE (Transesophageal Echocardiography), and MRA (Magnetic Resonance Angiography) or the clinical history records of their 14-day follow-up examinat
Index test:AI-assisted non-contrast CT

Sponsors

The First Affiliated Hospital of Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Presenting to the emergency department with non-traumatic acute chest pain (defined as pain, pressure, tightness or discomfort in the chest, shoulder, arm, neck, back, upper abdomen or jaw, as well as shortness of breath and fatigue); 2. The attending physician did not consider acute aortic syndrome as one of the differential diagnoses; 3. A CT scan covering the aortic range was performed; 4. Age > 18 years, regardless of gender.

Exclusion criteria

Exclusion criteria: 1. Clinical severity or other conditions that do not allow for a complete assessment or appropriate enrollment; 2. CT examination is mainly aortic CTA, enhanced chest CT or enhanced abdominal CT; 3. Pregnancy; 4. Inability to follow up; 5. Inability to obtain informed consent; 6. Refusal to participate in this study.

Design outcomes

Primary

MeasureTime frame
Positive Predictive Value, PPV;Sensitivity;

Secondary

MeasureTime frame
Negative Predictive Value, PPV;Specificity;

Countries

China

Contacts

Public ContactHongkun Zhang

The First Affiliated Hospital of Zhejiang University School of Medicine

1198050@zju.edu.cn+86 135 8823 0962

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 19, 2026