Acute attack of acute heart failure
Conditions
Interventions
Receive standardized heart failure treatment and individualized medication therapy, excluding rhBNP.:None
Receive standardized heart failure treatment combined with rhBNP:None
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.The patient had symptoms and signs of emergency heart failure, and was diagnosed with acute heart failure (ESC 2021 diagnostic criteria), LVEF<40%; 2.The patients were aged from 18 to 80 years old and had no history of exacerbation of heart failure (excluding the interference of chronic remodeling); 3.Patients received standardized treatment (diuretics+vasodilators ± positive inotropic drugs). 4.Patients and their families signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients complicated with infection, tumor and autoimmune diseases (to avoid interference of inflammatory indicators); 2.The patient received IL-1 ß antagonist or immunosuppressive therapy within 3 months; 3.The patient is allergic to any component of recombinant human brain natriuretic peptide, accompanied by cardiogenic shock or systolic blood pressure2.0 times the upper limit of normal value) and renal dysfunction (egfr<60); 5.Patients with hematological diseases, mental diseases or systemic diseases; 6.Women during pregnancy or lactation; 7.Patients participating in clinical research of other drugs;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-proBNP;Type of heart failure;Difference in GSDMD changes from baseline between the two groups after 72 hours of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rehospitalization time;Interleukin-6;Dyspnea;coronary heart disease;Interleukin-1 ß;weight;diabetes;Interleukin-18;edema;Tumor Necrosis Factor-alpha;height;New York Heart Association Classification;hypertension;Treatment plan;Cardiac ultrasound;Time of major adverse cardiovascular events;Long term medication;hs - CRP;Major Adverse Cardiovascular Events; | — |
Countries
China
Contacts
Public ContactLijun Cao
Qilu Hospital of Shandong University
Outcome results
None listed