Hypopharyngeal Carcinoma
Conditions
Interventions
De-escalation Surgery Group:None
Standard Surgery Group:None
Sponsors
Beijing Tongren Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years and <=75 years. 2. Histopathologically confirmed squamous cell carcinoma of the hypopharynx. 3. Clinical stage III or IVa at the time of primary treatment (according to the AJCC 8th edition of the Cancer Staging Manual). 4. Undergo radical surgery after at least 2 cycles of neoadjuvant therapy with standard regimens (TPF or TP+targeted or TP+immunotherapy, etc.). 5. Have complete pre-neoadjuvant therapy assessment, in-treatment efficacy assessment and post-operative follow-up information.
Exclusion criteria
Exclusion criteria: 1. History of other malignant tumours (except for malignant tumours that have been cured for more than 5 years). 2. Distant metastasis before neoadjuvant therapy (M1). 3. Disease progression (PD) assessed after neoadjuvant therapy. 4. Undergoing non-radical surgery (e.g. palliative resection). 5. Clinical data are severely lacking for efficacy and safety evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local Recurrence Rate;Overall Survival;Function Preservation Rate;Disease-Free Survival; | — |
Countries
China
Contacts
Public ContactJugao Fang
Beijing Tongren Hospital, Capital Medical University
Outcome results
None listed