Age-related macular degeneration
Conditions
Interventions
Faricimab group:None
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >50 years; 2. Confirmed diagnosis of nAMD (searched in the electronic medical record database for terms: exudative age-related macular degeneration, age-related macular degeneration, or macular degeneration, with prescription records of faricimab or aflibercept indicating disease activity and patient receiving treatment); 3.Best corrected visual acuity (BCVA) measured by standard logarithmic visual acuity chart >=0.05; 4.OCT scan of the macula (6x6 mm) showing pigment epithelial detachment (PED) height >50 µm within the ETDRS grid.
Exclusion criteria
Exclusion criteria: 1. Received anti-VEGF therapy within 60 days; 2. Intraocular pressure >30 mmHg or diagnosed with glaucoma; 3. Presence of MNV or PED caused by other conditions such as diabetic retinopathy, retinal vein occlusion, high myopia, or other diseases severely affecting vision (e.g., vitreous hemorrhage, rhegmatogenous retinal detachment); 4. Active periocular or ocular infection or inflammation in either eye (e.g., blepharitis, conjunctivitis, keratitis, scleritis, uveitis, endophthalmitis) at screening or baseline; 5. History of stroke or myocardial infarction within 3 months prior to screening; 6. Inability to comply with the study or follow-up procedures; 7. Pregnant or lactating women; 8. Uncontrolled systemic diseases; 9. Current or planned use of faricimab or aflibercept as outlined in the product information, or systemic use of medications known to be toxic to the lens, retina, or optic nerve.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The max height of PED; | — |
Secondary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity;Central macular thickness;The volume of PED;Activity of Macular Neovascularization; | — |
Countries
China
Contacts
Public ContactYuan Yuanzhi
Zhongshan Hospital, Fudan University
Outcome results
None listed