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An LLM-Based Exercise Prescription System for Digital Chronic Disease Management— Evidence from a Large-Scale Randomized Controlled Trial

An LLM-Based Exercise Prescription System for Digital Chronic Disease Management— Evidence from a Large-Scale Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600118939
Enrollment
Unknown
Registered
2026-02-13
Start date
2026-03-03
Completion date
Unknown
Last updated
2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, type 2 diabetes

Interventions

Human arm (control):A standardized 21-day digital chronic disease management program delivered in routine WeChat-based communities/mini-programs. Participants voluntarily submit physical-activity logs
EPS–human arm (intervention):A standardized 21-day digital chronic disease management program delivered in routine WeChat-based communities/mini-programs. Participants voluntarily submit physical-acti

Sponsors

City University of Hong Kong, Department of Systems Engineering (SYE)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: General inclusion criteria (applicable to all participants) 1. Participants have enrolled in a digital chronic disease management program delivered via Ping An Health–operated WeChat communities and/or a WeChat Mini Program (a routine operational setting rather than a single-site, offline research center). 2. Participants voluntarily record/submit exercise (physical activity) information within the community (e.g., activity type and duration) and receive exercise feedback during the program (intervention arm: feedback generated by EPS and reviewed by professional health managers before delivery; control arm: feedback written manually by health managers). 3. Health managers complete eligibility screening, electronic informed consent, and enrollment according to routine operational workflows, followed by group assignment/randomization (either 1:1 individual randomization or community-level randomization, depending on the protocol). 4. Participants are able to complete outcome data collection/follow-up during the program (e.g., providing routine monitoring data such as weight or blood glucose at program initiation and completion; and an optional end-of-program questionnaire). 5. Age between 20 and 60 years. Cohort-specific inclusion criteria 6. Weight management/weight-loss program: participants have purchased or registered for Ping An Health’s weight management (weight-loss) service and joined the corresponding community program. 7. Glycemic-control program: participants have joined the community-based glycemic-control program and are able to provide blood glucose–related data (e.g., fasting blood glucose) as part of routine monitoring.

Exclusion criteria

Exclusion criteria: General exclusion criteria (applicable to all participants) 1.Refusal to participate in the study (unwilling to participate). 2.Failure to provide electronic informed consent (including refusal to consent). 3.Age not within 20–60 years. 4.Unable to use smart devices (e.g., a smartphone) or unable to complete the required online interactions and data submission via WeChat/Mini Program. Cohort-specific exclusion criteria 5.Weight-loss cohort: not part of the target population for the weight management (weight-loss) service (e.g., not purchased or not registered for Ping An Health’s weight management service, or not enrolled in the corresponding community program). 6.Glycemic-control cohort: not part of the glycemic-control program population (e.g., not enrolled in the glycemic-control community program and/or unable to be included in the program workflow).

Design outcomes

Primary

MeasureTime frame
body weight;fasting plasma glucose;

Countries

China

Contacts

Public ContactSiyang Gao

City University of HongKong

siyangao@cityu.edu.hk+852 3442 4759

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 19, 2026