Oral leukoplakia
Conditions
Interventions
Bleomycin Treatment Group:Lesions were preconditioned when necessary, followed by topical application of bleomycin (BLM) via wet dressing.
Sponsors
Peking University School and Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with clinically and histopathologically confirmed oral leukoplakia (OLK); 2. Aged >= 18 years, with no restriction on sex; 3. Patients with lesions larger than 1 cm in maximum diameter who are not suitable candidates for local excisional treatment; 4. Able and willing to provide written informed consent to participate in the clinical trial.
Exclusion criteria
Exclusion criteria: 1. Patients with malignant transformation of oral leukoplakia (OLK); 2. Patients who have undergone clinical examination only without histopathological confirmation; 3. History of radiotherapy to the head and neck region; 4. Presence of other malignancies outside the oral cavity; 5. Pregnant or breastfeeding individuals, and minors; 6. Patients with rapidly progressive systemic diseases; 7. History of HIV infection or active hepatitis B or hepatitis C; 8. Patients unable to comply with the study protocol for any reason; 9. History of betel quid chewing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of change in lesion area; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in clinical symptoms;Pathological and molecular changes;Cytological changes;Safety outcomes; | — |
Countries
China
Contacts
Public ContactPeiru Zhou
Peking University School of Stomatology
Outcome results
None listed