Drug-resistant epilepsy
Conditions
Interventions
Single set:Auricular vagus nerve modulation
Sponsors
Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Subjects must meet all of the following conditions: (1) Clearly having drug-resistant epilepsy and requiring routine SEEG treatment; Criteria for drug-resistant epilepsy: After taking two or more antiepileptic drugs on schedule, at sufficient doses, and with blood concentrations within the effective range, epilepsy seizures cannot be effectively controlled after regular, systematic treatment for at least 12 months, with daily seizures or an average of 1-2 seizures per month; (2) Having normal communication abilities; (3) Age range: 18-60 years, gender unrestricted; (4) Not having received similar neuromodulation training.
Exclusion criteria
Exclusion criteria: (1) Unable to cooperate with the test; (2) Previously undergone cranial surgery or intracranial electrode implantation; (3) Have other comorbidities and have already received or require implantation of a pacemaker, defibrillator, or cochlear implant; (4) Medication use: currently taking drugs that may affect central nervous system function; (5) Skin issues: have skin infections, wounds, or other skin problems in the area of contact with the neuromodulation device; (6) Psychological dependence: history of drug abuse or alcohol dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in seizure frequency and the functional connectivity strength between the epileptic focus and the default mode network in epilepsy patients after one week of continuous taVNS intervention; | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference between the reaction time and accuracy of memory tests in epilepsy patients on the day of the first taVNS intervention compared with baseline;Difference in functional connectivity strength between the patient's epileptic focus and the default mode network on the day of the first taVNS intervention compared to baseline;After one week of continuous taVNS intervention, the difference in reaction time and accuracy of memory tests in epilepsy patients compared with baseline;Half a month after the end of taVNS intervention, the difference in seizure frequency in epilepsy patients compared to baseline;Half a month after taVNS intervention, the reaction time and accuracy of memory tests in epilepsy patients were different from baseline;Half a month after the end of taVNS intervention, the difference in functional connectivity strength between the patient's epileptic focus and the default mode network compared to baseline; | — |
Countries
China
Contacts
Public ContactYang Hui
Second Affiliated Hospital of Army Medical University
Outcome results
None listed