cataract
Conditions
Interventions
cataract patients:None
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients 1.Age 50 to 85 years (including 50 and 85 years), no gender restrictions; 2.Meets diagnostic criteria for bilateral cataracts; 3.Patients scheduled for bilateral phacoemulsification with intraocular lens implantation; 4.Able and willing to comply with all follow-up plans; 5.Voluntarily agree to participate in this study and provide written informed consent, unless informed consent is waived with approval from the ethics committee; Healthy Controls 1. Age 50–85 years (including 50 and 85), no gender restrictions; 2. Able and willing to comply with all follow-up plans; 3. Voluntarily agree to participate in this study and provide written informed consent, unless informed consent can be waived with the approval of the Ethics Committee.
Exclusion criteria
Exclusion criteria: 1.Systemic diseases that may affect postoperative outcomes, such as patients with unstable blood glucose control in diabetes; 2.Amblyopia, strabismus, glaucoma, corneal diseases, severe retinal diseases, and other ocular conditions that may compromise postoperative results; 3.History of ocular trauma or prior ocular surgeries that may confound observation findings; 4.Pregnant or lactating women; 5.Current or past history of traumatic brain injury, cerebrovascular disease (e.g., stroke), neurological disorders (e.g., epilepsy, Alzheimer's disease, Parkinson's disease), or psychiatric conditions (e.g., depression, schizophrenia); 6.History of alcohol dependence or substance abuse; 7.Presence of depressive symptoms, intellectual impairment, dementia symptoms, or sleep disorder symptoms; 8.Working memory capacity below 3 or inability to complete working memory tasks; 9.Claustrophobia or metallic implants that do not meet MRI safety standards; 10.Inability to comply with follow-up visits as directed; 11.Other circumstances where the investigator determines the patient is unsuitable for enrollment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the connectivity of visual cortex, white matter fiber tracts, and spontaneous brain network fluctuations 7-30 days and 90-120 days post-surgery compared to pre-surgery;changes in amplitude of evoked potentials from preoperative levels at 7-30 days and 90-120 days postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in visual acuity, subjective refraction, intraocular pressure, slit-lamp examination, and iTrace examination results compared to pre-operation; | — |
Countries
China
Contacts
Public ContactGuo Tao
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed