Depressive disorder
Conditions
Interventions
Trial Group:Conventional drug therapy (sertraline 50-100mg qd) combined with bright light therapy (light intensity 1000lx, 30 minutes daily, in the morning from 7 to 9 AM)
Control Group:Conventional drug therapy (sertraline 50-100mg qd) combined with placebo light therapy (light intensity 50lx, 30 minutes daily, in the morning from 7 to 9 AM)
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.The age must satisfy >=12 years old and 17 points, DSRSC score > 15 points; 5.Signed informed consent form by legal guardian, voluntary participation.
Exclusion criteria
Exclusion criteria: 1.Comorbid with other psychiatric disorders (such as bipolar affective disorder, schizophrenia, etc.) or diagnosed with seasonal affective disorder; 2.Patients with severe suicide risk or a history of suicide attempts; 3.Currently taking beta-blockers; 4.Comorbid with serious somatic diseases or organic brain diseases; 5.Accompanied by ocular diseases, systemic diseases affecting the retina, or currently using photosensitizers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate from baseline to week 2 post-intervention (defined as >=50% reduction in HAMD-17 total score from baseline at week 2); | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in HAMD-17 score;Change in HAMA score;Change in DSRSC score;Change in PSQI score;Change in MEQ-5 score;Safety outcomes (including adverse events and serious adverse events); | — |
Countries
China
Contacts
Public ContactLuo Xian
Southern Medical University Southern Hospital
Outcome results
None listed