Depressive Disorder
Conditions
Interventions
sham rTMS+ sham taVNS:Sham repetitive transcranial magnetic stimulation (sham rTMS) and Sham transcutaneous auricular vagus nerve stimulation (sham taVNS)
sham rTMS+active taVNS:Sham repetitive transcranial magnetic stimulation (sham rTMS) and transcutaneous auricular vagus nerve stimulation (taVNS)
active rTMS+sham taVNS:Repetitive transcranial magnetic stimulation ( rTMS) and Sham transcutaneous auricular vagus nerve stimulation (sham taVNS)
active rTMS+ active taVNS:Repetitive transcranial magnetic stimulation ( rTMS) and Transcutaneous auricular vagus nerve stimulation (taVNS)
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1.Adult patients with depressive disorder aged 18-30 years. 2.Montgomery-Åsberg Depression Rating Scale (MADRS) score = 12. 3.Hamilton Depression Rating Scale, 24-item (HAMD-24) score = 8. 4.No history of other psychiatric disorders (e.g., epilepsy, obsessive-compulsive disorder, post-traumatic stress disorder, social phobia). 5.No history of dependence on psychotropic medications. 6.No history of organic brain diseases. 7.Absence of severe physical illnesses and no comorbid other psychiatric disorders. 8.No history of acute or chronic infections, trauma, inflammation, fever, or allergies within the past two weeks. 9.No history of alcohol or substance abuse. 10.Right-handed. 11.No prior treatment with rTMS or taVNS. 12.No severe hearing impairment or history of skin allergies (to avoid obstacles during intervention). 13.Voluntary provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Comorbid other psychiatric disorders (e.g., bipolar disorder, schizophrenia). 2.History of substance abuse (within the past 6 months). 3.History of epilepsy or presence of implanted electronic devices (e.g., cardiac pacemakers). 4.Deemed unsuitable for participation by the investigator (e.g., inability to cooperate with the treatment). 5.Severe cardiovascular diseases (e.g., uncontrolled hypertension, arrhythmia). 6.Pregnant or lactating women. 7.Previous intolerance to transcranial magnetic stimulation or electrical stimulation. 8.Participation in other clinical trials (within the past month).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-?sberg Depression Rating Scale (MADRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale, 24-item (HAMD-24);Treatment Emergent Symptom Scale(TESS);ECG data; | — |
Countries
China
Contacts
Public ContactMengqian li
The first affiliated hostipal of nanchang university
Outcome results
None listed