Osteoarthritis of the hip and knee
Conditions
Interventions
Group K1:Administer 0.125 mg/kg of esketamine during anaesthetic induction.
Group K2:Administer 0.25 mg/kg of esketamine during anaesthetic induction.
Group N:Administer an equivalent volume of physiological saline during anaesthetic induction.
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–65 ; 2. Elective hip or knee arthroplasty; 3. ASA I–II; 4. Voluntary use of patient-controlled intravenous analgesia (PCIA).
Exclusion criteria
Exclusion criteria: 1. Anaesthesia duration >3 hours; 2. Patients with severe psychiatric disorders (anxiety disorders, depression, bipolar disorder, schizophrenia, etc.), history of epilepsy or family history of psychiatric illness, cognitive impairment, or inability to communicate effectively; 3. Patients with a history of alcohol abuse or substance misuse; 4. Patients on long-term psychiatric medication (e.g., clozapine, olanzapine, chlorpromazine, haloperidol); 5. BMI >=30 kg/m² or <=18 kg/m²; 6. Patients with contraindications to esketamine use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anaesthetic recovery time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute postoperative pain;Adverse events in the recovery room;PACU observation period;Quality of recovery;Postoperative subjective recovery quality;Quality of sleep on the night following surgery;Postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactLiu Yingzhu
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed