Postoperative sleep disorder
Conditions
Interventions
experimental group:30 minutes before the end of the surgery, an initial dose of esketamine at 0.2mg/kg (10ml) was administered intravenously. Subsequently, a continuous intravenous analgesia pump was
control group:Thirty minutes before the end of the surgery, an equal volume (10ml) of normal saline was infused at the same rate. Then, a venous analgesia pump was used to provide pain relief. The con
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–75 years; 2. ASA grade I–III; 3. BMI between 18.5 and 30 kg/m²; 4. Thoracoscopic pulmonary resection; 5. No preoperative sleep disturbance, with a preoperative AIS score <6 (0–5 points).
Exclusion criteria
Exclusion criteria: 1. Patients who refuse to participate in the study; 2. Preoperative AIS score >=6, indicating preoperative sleep disturbance; 3. Undergoing emergency surgery; 4. Allergy or contraindication to esketamine; 5. History of psychiatric disorders or long-term use of medication for psychological illnesses; 6. History of alcohol or substance abuse; 7. Severe sensory organ deficits (e.g., visual or hearing impairment), cognitive dysfunction, or inability to communicate normally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of sleep disorders within 3 days after the surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep efficiency within 3 days after surgery, percentage of rapid eye movement sleep, percentage of unstable sleep, percentage of stable sleep, and number of awakenings;The pain condition and the amount of opioid consumption three days after the surgery;The levels of anxiety and depression within 3 days after the surgery;The recovery status within 3 days after the operation;Postoperative adverse reactions;Postoperative hospital stay duration; | — |
Countries
China
Contacts
Public ContactZhou Huidan
Anesthesiology Department of Zhejiang Cancer Hospital
Outcome results
None listed