Postoperative Gastrointestinal Function
Conditions
Interventions
Oliceridine Group:Analgesia using oliceridine administered before the end of surgery and postoperatively
Sufentanil Group:Analgesia using Sufentanil administered before the end of surgery and postoperatively
SHR8554 Group:Analgesia using SHR8554 administered before the end of surgery and postoperatively
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.American Society of Anesthesiologists (ASA) physical status classification of II or III; 2.Age between 18 and 75 years; 3.Scheduled to undergo laparoscopic partial colorectal resection surgery; 4.Informed of the study content and voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals with a body mass index (BMI) exceeding 35 kg/m²; 2. History of airway management difficulties or delayed extubation; 3. Known gastrointestinal motility disorders; 4. Previous abdominal surgery; 5. Preoperative gastrointestinal haemorrhage (blood loss exceeding 800 mL); 6. Presence of psychiatric disorders (e.g., schizophrenia, depression) or cognitive impairment; 7. Use of opioid or non-opioid analgesics for chronic pain; 8. Allergy to study drugs (tigelidine, oseltamivir, sufentanil); 9. Hepatic or renal impairment (ALT and/or AST values >1.5 times upper limit of normal, creatinine <30µmol/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| I-FEED score on postoperative day 3;Pain score at postoperative 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first flatus; | — |
Countries
China
Contacts
Public ContactWang zhongyun
The First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed