None
Conditions
Interventions
Control group (lidocaine-prilocaine group):Lidocaine–prilocaine cream
Intervention group(brimonidine combined with lidocaine-prilocaine):Lidocaine–prilocaine cream plus brimonidine
Sponsors
The Third Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Male or female subjects of yellow race, aged between 18 and 60 years (inclusive); 2.Participants with self-requested improvement of skin tone or texture; 3.Presence of bilaterally symmetrical facial treatment areas; 4.Ability to understand and comply with the study requirements and to complete follow-up visits; 5.Consent to randomization for placement into the microneedling therapy group or the microinjection therapy group; 6.Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Do not agree to sign the informed consent form; 2. Individuals preparing for pregnancy, pregnant, or breastfeeding; 3. Individuals with liver or kidney dysfunction; 4. Individuals who are highly allergic to amide-type local anesthetics or any components of compound lidocaine cream; 5. Individuals allergic to any components of bromonidine tartrate or bromonidine tartrate eye drops; 6. Patients being treated with monoamine oxidase inhibitors and patients using antidepressants that affect norepinephrine transmission; 7. Patients with congenital or idiopathic methemoglobinemia; 8. Patients with syndromes related to vascular dysfunction, cerebral or coronary artery insufficiency, Raynaud's phenomenon, orthostatic hypotension, thromboangiitis obliterans, or severe cardiovascular malformations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score (VAS, Visual Analog Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient satisfaction;Erythema score;Efficacy assessment;Edema score; | — |
Countries
China
Contacts
Public ContactLi Xueqing
The Third Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed