Diabetes
Conditions
Interventions
AB Sequence Group:Auditory Closed-Loop Stimulation (Intervention group with 'rising phase' first followed by 'declining phase')
BA Sequence Group:Auditory Closed-Loop Stimulation (Intervention group with the 'increasing phase' following the 'declining phase')
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 60 years old (inclusive); 2.No restriction on gender; 3.Self-reported good health status, good sleep quality, stable sleep-wake rhythm over the past 6 weeks, and normal blood glucose levels; 4.Voluntary participation with a signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.Current diagnosis of neuropsychiatric, sleep, metabolic, immune, cardiovascular, liver or kidney-related diseases; history of smoking, alcohol addiction, or substance abuse; or use of any medication for treating the aforementioned conditions (based on self-report); 2.Pittsburgh Sleep Quality Index (PSQI) > 5, or Epworth Sleepiness Scale (ESS) > 11; 3.Recurrent hypoglycemic events (= 3 times) within the past month, or the first fasting continuous glucose monitoring value on the day before monitoring > 6.7 mmol/L or 28.0 or < 18.0; 5.Currently engaged in shift work; 6.Female during pregnancy or the perinatal period; 7.Severe hearing impairment; 8.Any other condition considered by the investigator as unsuitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Slow oscillation;Coefficient of variation;Time in range;Spindle;Time below range;Time above range;Slow oscillation-spindle coupling; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of non-rapid eye movement sleep stages;Proportion of slow wave sleep; | — |
Countries
China
Contacts
Public ContactAi Sizhi
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed