Clinical Research on Modified Chaihu Jia Longgu Muli Decoction in the Treatment of Parkinson's Disease Complicated with Rapid Eye Movement Sleep Disorder

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600118848

Enrollment

Unknown

Registered

2026-02-11

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease Complicated with Rapid Eye Movement Sleep Disorder

Interventions

Treatment Group:Basic treatment plus modified Chaihu Jia Longgu Muli Tang (Chaihu 10g, Huangqin 10g, Fbanxia 10g, Dangshen 10g, Dazao 12g, Shengjiang 6g, Longgu 30g, Muli 30g, Guizhi 10g, Fuling 15g,

syndrome differentiation addition: add Tiansheng 6g for phlegm-heat stirring wind type, add Danshen 15g for qi stagnation and blood stasis type, add Danggui 10g for qi and blood deficiency type, add B

Control Group:Basic treatment (including Madopar, Pramipexole and other anti-Parkinson's disease drugs), course of treatment 4 weeks

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Age >=18 years old and <=80 years old. 2.Patients who visited Huzhou Central Hospital and were diagnosed with Parkinson's disease combined with rapid eye movement sleep disorder. 3. Voluntarily participated in this study and signed the informed consent form. 4. Not taking any sedative-hypnotic or antipsychotic drugs for treatment. 5. Hoehn -Yahr grade 1-3.

Exclusion criteria

Exclusion criteria: 1. Not meeting the inclusion criteria. 2.Vulnerable groups other than the elderly include people with mental illness, people with cognitive impairment, critically ill patients, minors, pregnant women, and the illiterate. 3. Unable to cooperate in completing PSG monitoring. 4. Abnormal liver and kidney functions and other serious diseases. 5. Unable to cooperate in taking traditional Chinese medicine.

Design outcomes

Primary

Measure	Time frame
Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire (RBDSQ) Score;Pittsburgh Sleep Quality Index (PSQI) Score;Polysomnography (PSG) Data;	—

Secondary

Measure	Time frame
Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) Score;Traditional Chinese Medicine Syndrome Score for Tremor;Serum Melatonin Level;	—

Countries

China

Contacts

Public ContactAi Zongyao

Huzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University

534677603@qq.com+86 138 1929 2712

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 19, 2026