Thyroid cancer surgery
Conditions
Interventions
A Group (Lidocaine Group):Intravenous lidocaine 1 mg/kg administered 1 minute before induction
B Group (Remifentanil Group):Remifentanil 0.5 µg/kg administered 1 minute before induction
C Group (Dexmedetomidine Group):Dexmedetomidine 0.5 µg/kg infused via pump 10 minutes before induction
D Group (Blank Control Group):No drug administration
Sponsors
Jilin University-China-Japan Friendship Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Female, aged 18 years or older and less than 60 years; 2. American Society of Anesthesiologists (ASA) classification: I-III; 3. BMI: 18.5 - 24.9 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Anesthesia drug allergy; 2. Abnormal blood coagulation; 3. Preoperative gastrointestinal obstruction; 4. Severe heart disease; 5. Severe sinoatrial node dysfunction (II or III degree atrioventricular conduction block); 6. Congestive heart failure; 7. Liver and kidney dysfunction or cognitive impairment; 8. Hypoxemia; 9. Hypoalbuminemia; 10. Long-term use of anti-inflammatory drugs and hormones.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Suppression of cough during tracheal intubation;Cough score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic stability during induction period;Incidence of postoperative sore throat and nausea/vomiting;Hemodynamics during induction period;Use of vasopressor agents;Bispectral index (BIS) value;Presence or absence of postoperative sore throat;Safety outcomes (including severe hypotension, serious arrhythmia, respiratory depression, delayed emergence, allergy, refractory hypotension, bradycardia); | — |
Countries
China
Contacts
Public ContactZhu Zhihua
Jilin University-China-Japan Friendship Hospital
Outcome results
None listed