hepatocellular carcinoma
Conditions
Interventions
Radiofrequency ablation combined with recombinant human type-5 adenovirus and PD-1 monoclonal antibodies for treatment group:None
RFA-only treatment group:None
Sponsors
The 958th Hospital of Army
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosed as primary hepatocellular carcinoma, using pathological examination as the standard or referring to the diagnostic criteria of the Chinese Liver Cancer Diagnosis and Treatment Guidelines (2023 edition); 2.Age range: 18-75 years old; 3.Single tumor with a diameter of <= 5cm; 4.Have not received H101 treatment or regular use of PD-1 monoclonal antibody treatment in the past; 5.The tumor has not invaded the secondary or lower branches of the hepatic artery, portal vein, or hepatic vein; 6.The patient's liver function is classified as Child A or Child B and reaches Child A after treatment; 7.Important organ function can tolerate RFA, without contraindications related to oncolytic virus therapy and PD-1 monoclonal antibody therapy.
Exclusion criteria
Exclusion criteria: 1.Receive other anti-tumor treatments or liver transplantation during the trial period; 2.Patients with extrahepatic metastasis, lymph node metastasis, or concomitant tumors of other systems; 3.Child C liver function, Child B liver function that cannot be improved by treatment; 4.Severe coagulation dysfunction: platelet count4 seconds or international normalized ratio INR>1.5; 5.Cases of combined refractory ascites, hepatic encephalopathy, and gastrointestinal bleeding; 6.ECOG physical status score >= 2; 7.Patients who have lost follow-up.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Complete ablation rate;Ablation range;complications;hospital stay; | — |
Primary
| Measure | Time frame |
|---|---|
| recurrence-free survival rates;overall survival rates;local tumor progression rates;Alpha fetoprotein levels; | — |
Countries
China
Contacts
Public ContactWu Guodong
The 958th Hospital of Army
Outcome results
None listed