Breast surgery patients
Conditions
Interventions
Pure ropivacaine control group:After anesthesia, 20ml of 0.375% ropivacaine will be applied for SAPB on the affected side
Moderate-dose esketamine group:After anesthesia, 0.375% ropivacaine 20ml+0.25mg/kg esketamine was applied to the affected side of SAPB
High-dose esketamine group:After anesthesia, 0.375% ropivacaine 20ml+0.5mg/kg esketamine was applied to the affected side of SAPB
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
Female
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1: The age is between 45 and 60 years old; 2: Body mass index (BMI) between18 and 30kg/m^2,improved Kupperman score>6; 3: American Association of Anesthesiologists (ASA) Grade ?-?, with good cardiopulmonary function and no obvious surgical contraindications,no obvious contraindications for surgery; 4: Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1: Contraindications of nerve block: coagulation dysfunction, puncture site infection, deformity or tumor, etc. 2: Complicated with dysfunction of important organs such as heart, liver and kidney. 3: Uncontrolled hypertension or poor blood pressure control. 4: Complicated with chronic pain or taking analgesic drugs for a long time. 5: Complicated with central nervous system diseases or psychosis. 6: Allergies to the drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score;CAM score;PANAS(The Positive and Negative Affect Scale) score;Numerical Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions (nausea and vomiting);Rescue analgesia rate;Postoperative chronic pain rate; | — |
Countries
China
Contacts
Public ContactZhang Zhongjun
Affiliated Hospital of Jiangnan University
Outcome results
None listed