Parkinson's Disease
Conditions
Interventions
Gold Standard:2015 International Movement Disorder Society clinical diagnostic criteria for parkinson's disease
Index test:non-invasive fundus retinal detection technology (functional optical coherence tomography angiography-retinal neurovascular coupling (fOCTA-rNVC) detection technology)
Sponsors
The second affiliated hospital of Zhejiang University school of medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40-80 years; 2. Parkinson's Disease Group: Patients who meet the 2015 International Movement Disorder Society clinical diagnostic criteria for Parkinson's disease, with a Hoehn and Yahr stage of 1 to 2.5 and a disease duration of =3 months; vascular: confirmed by brain MRI showing leukoaraiosis/lacunar infarction), with a disease duration of =1 year; 5. Healthy Control Group: Individuals with no parkinsonian symptoms (confirmed by neurological examination) and no use of antipsychotic/dopaminergic medications in the past 3 months; 6. All subjects have provided written informed consent and are willing to comply with the study procedures;
Exclusion criteria
Exclusion criteria: 1. Presence of severe ocular fundus diseases, such as glaucoma, cataract, retinal detachment, macular degeneration, etc; 2. Inability to tolerate the non-invasive fundus retinal detection; 3. Known allergy or investigator-suspected high risk of allergy to anti-PD drugs; 4. Presence of severe cardiovascular or cerebrovascular diseases (e.g., coronary heart disease, myocardial infarction, stroke, etc.), hepatic or renal dysfunction, cancer, or other conditions that may affect the prognosis; 5. Pregnancy or lactation; 6. Presence of active infectious diseases (e.g., tuberculosis, AIDS) or systemic inflammatory diseases (e.g., rheumatoid arthritis); 7. Presence of psychiatric disorders;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specificity;Area under the receiver operating characteristic curve (AUC); | — |
Countries
China
Contacts
Public ContactFeng Gao
The second affiliated hospital of Zhejiang University school of medicine
Outcome results
None listed