Depressive state
Conditions
Interventions
Control group:Pump injection of sodium chloride injection
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years, regardless of gender; 2.ASA physical status classification 17 points; primary school education: >20 points; middle school or above education: >24 points); 5.Preoperative assessment with the Montgomery-Åsberg Depression Rating Scale (MADRS) and Patient Health Questionnaire-9 (PHQ-9) indicating comorbid depressive state (MADRS > 6 points; PHQ-9 > 4 points); 6.Have agreed to participate in the study and signed the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Have severe visual, auditory, and linguistic impairments; 2.Refuse to use the patient-controlled analgesia (PCA) pump; 3.Have comorbid contraindications to neuraxial anesthesia; 4.Have a recent history of gastrointestinal diseases and use of antibiotics or probiotics; 5.Have comorbid contraindications to esketamine use: intracranial aneurysm, arteriovenous malformation, intracerebral hemorrhage, cerebral infarction within 3 months, glaucoma, uncontrolled hypertension, unstable angina pectoris, and schizophrenia or other severe mental illnesses;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy rate of antidepressant effect of esketamine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse Reactions of Esketamine in Elderly Patients Undergoing Non-General Anesthesia Surgery;The efficacy of esketamine in improving postoperative depression in elderly patients with preoperative depression undergoing knee arthroplasty;Correlation between the Antidepressant Mechanism of Esketamine and Gut Microbiota as well as Inflammatory Response;Safety of Esketamine in Elderly Patients Undergoing Non-General Anesthesia Surgery; | — |
Countries
China
Contacts
Public ContactTianlong Wang
Xuanwu Hospital Capital Medical University
Outcome results
None listed