Post-Induction Hypotension in Preoperatively Frail Elderly Patients
Conditions
Interventions
Trial Group (Induction Group):In the experimental group, a 5-mL syringe labeled with a white tag (containing a mixture of palonosetron hydrochloride 0.075 mg and normal saline) was administered before
Control Group (Conclusion Group):In the control group, a 5-mL syringe labeled with a white tag (containing normal saline) was administered before anesthesia induction. At the conclusion of surgery, fo
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 60-85 years; 2. Elderly patients classified as ASA physical status ? to ?; 3. Scheduled for non-cardiac surgery under general anesthesia; 4. FFP score >= 3 points;
Exclusion criteria
Exclusion criteria: 1.History of severe hepatic impairment, defined as Child-Pugh Class C; 2.Prolonged QT interval on preoperative electrocardiogram (ECG); 3.Refusal to undergo surgery or to participate in this study; 4.Concomitant use of antidepressant or antipsychotic medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of post-induction hypotension, defined as the occurrence of a mean arterial pressure (MAP) less than 65 mmHg within 15 minutes after the initiation of general anesthesia induction.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The area under the curve (AUC) for mean arterial pressure (MAP) below 65 mmHg within 15 minutes post-anesthesia induction.;The incidence of a greater than 20% reduction in mean arterial pressure (MAP) from baseline within 15 minutes after anesthesia induction.;The area under the curve (AUC) for mean arterial pressure (MAP) reduction exceeding 20% from baseline within 15 minutes after anesthesia induction.;The number and proportion of patients exhibiting a reduction in mean arterial pressure (MAP) exceeding 10% from baseline within 15 minutes after anesthesia induction.;The area under the curve (AUC) for mean arterial pressure (MAP) reduction exceeding 10% from baseline within 15 minutes after anesthesia induction.;The number and proportion of patients exhibiting a reduction in heart rate (HR) exceeding 10% from baseline within 15 minutes after anesthesia induction.;The area under the curve (AUC) for heart rate (HR) reduction exceeding 10% from baseline within 15 minutes after anesthesia induction.;Postoperative nausea and vomiting (PONV)-related scores assessed in the Post-Anesthesia Care Unit (PACU) and at 24 hours, 48 hours, and day 5 after surgery.;Dosage of anesthesia induction agents;Consumption of vasoactive agents within 15 minutes after anesthesia induction: doses of phenylephrine, ephedrine, atropine, urapidil, and esmolol.;Pain Visual Analog Scale (VAS) scores assessed in the Post-Anesthesia Care Unit (PACU) and at 24 hours (T24h), 48 hours (T48h), and postoperative day 5.;Quality of Recovery-15 (QoR-15) scores at 24 hours, 48 hours, and postoperative day 5.;Occurrence of delirium assessed in the Post-Anesthesia Care Unit (PACU) and at 24 hours (T24h), 48 hours (T48h), and postoperative day 5.;Sedation level assessed using the Ramsay Sedation Scale at 15 minutes after extubation.;Emergence time;Extubation time;Adverse events (including laryngospasm, oxygen desaturation, coughing, hemorrhage, pharyngeal edema, intraoperative awareness, etc.);Adverse reactio | — |
Countries
China
Contacts
Public ContactZhang Yueying
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed