Chronic obstructive pulmonary disease (COPD)
Conditions
Interventions
Control Group:Conventional Pressure Support Ventilation Breathing Exercise
Experimental Group:Early implementation of low-level Pressure Support Ventilation combined with endotracheal high-flow oxygen therapy and training during mechanical vent
Sponsors
Hangzhou Linping Hospital of Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Diagnosed with AECOPD (meeting GOLD criteria) complicated by respiratory failure requiring endotracheal intubation. 2.Age >=18 years. 3.Eligible for early respiratory rehabilitation (e.g., hemodynamically stable, FiO2 <=60%, PEEP =8 cmH2O). 4.Awake after discontinuation of sedatives and analgesics. 5.Informed consent obtained and signed by the patient's family or legal representative.
Exclusion criteria
Exclusion criteria: 1.Family refusal to participate in the clinical trial. 2.Comorbidities that significantly interfere with weaning training, including but not limited to: Intracerebral hemorrhage or massive cerebral infarction with impaired consciousness; Decompensated heart failure, severe cardiogenic shock affecting hemodynamics; Decompensated liver failure (Child-Pugh Class C) with hepatic coma; Renal failure with anuria requiring immediate bedside blood purification therapy. 3.Neurological diseases resulting in restricted or complete loss of spontaneous respiratory function. 4.Prior tracheostomy with long-term ventilator dependence. 5.Severe immunocompromised patients. 6.Terminal status (e.g., advanced cancer) with an expected survival time <72 hours, or family decision to withhold aggressive treatment. 7. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reintubation within 28 days post-extubation due to aspiration or impaired respiratory drive.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Spontaneous Breathing Trial (SBT);Weaning Parameters Related to Respiratory Mechanics; | — |
Countries
China
Contacts
Public ContactWang XiaoLiang
Hangzhou Linping Hospital of Integrated Traditional Chinese and Western Medicine
Outcome results
None listed