Hypertension, with or without complications such as hypertensive heart disease, coronary heart disease, and heart failure.
Conditions
Interventions
Hypertension (HTN) Group:None
Control Group:None
Hypertension with Ischemic Heart Disease (HTN + IHD) Group:None
Hypertensive Heart Disease (HHD) Group:None
Sponsors
The First Affiliated Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for the Control Group (all must be met): (1) Age >=18 and =18 and <=80 years, regardless of gender; (2) A clear diagnosis of primary hypertension, meeting the criteria of the Chinese Guidelines for the Prevention and Treatment of Hypertension or the ESC/ESH hypertension guidelines; (3) Complete clinical case data; (4) Availability of discarded blood samples (plasma and/or serum) without hemolysis or contamination.
Exclusion criteria
Exclusion criteria: 1.Control Group: (1) History of definite acute infection, malignancy, or systemic inflammatory disease; (2) Diagnosed cardiomyopathy; (3) Severe valvular heart disease; (4) Diagnosed secondary hypertension; (5) Severe liver dysfunction (ALT or AST >= 3 times the upper limit of normal) or confirmed active hepatitis or decompensated cirrhosis; (6) Moderate to severe renal insufficiency (estimated eGFR = 3 times the upper limit of normal) or confirmed active hepatitis or decompensated cirrhosis; (6) Moderate to severe renal insufficiency (estimated eGFR < 60 ml/min/1.73 m^2); (7) Severe endocrine disorders, including but not limited to uncontrolled hyperthyroidism, hypothyroidism, or diabetes; (8) Any other condition deemed unsuitable for inclusion in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transcriptional and translational expression levels of RIP3, ZBP1, SULF1, and other genes;Blood routine and biochemical indicators;Echocardiography, chest CT, abdominal and urinary system color Doppler ultrasound; | — |
Countries
China
Contacts
Public ContactHuang Zhengrong
The First Affiliated Hospital of Xiamen University
Outcome results
None listed