Alzheimer’s Disease, AD
Conditions
Interventions
ATT group:none
Non-ATT group:none
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 45 years; 2. Presence of MMSE score >= 18 or CDR-SB score <= 6; 3. Diagnosis of Alzheimer's disease confirmed by both biomarkers and clinical symptoms; 4. Informed consent form signed by the patient or legal guardian.
Exclusion criteria
Exclusion criteria: 1. Unwilling or unable to cooperate with the required examinations; 2. Cognitive impairment secondary to neurological infectious diseases (e.g., HIV, neurosyphilis, autoimmune encephalitis) or systemic diseases (e.g., diabetes, thyroid dysfunction; 3. Presence of severe impairment in vital organs (e.g., cardiac, hepatic) or psychiatric disorders; 4. Presence of any contraindications to neuroimaging examinations; 5. Inability to cooperate with or complete the required follow-up assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in CDR-SB from baseline at 2-year follow-up;Incidence of adverse drug reactions and amyloid-related imaging abnormalities (ARIA); | — |
Secondary
| Measure | Time frame |
|---|---|
| The degree of increase in Aß-PET SUVR values;Activities of daily living; | — |
Countries
China
Contacts
Public ContactSheng Zhang
Zhejiang Provincial People's Hospital
Outcome results
None listed