stroke
Conditions
Interventions
Treatment group: Multi-Feedback BCI-Controlled Lower Limb Cycling Training + Conventional Rehabilitation Therapy.
Sponsors
Zhejiang Rehabilitation Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of stroke conforming to the Chinese Guidelines for the Diagnosis of Various Cerebrovascular Diseases (2019), confirmed by cranial CT or MRI. 2. First onset of stroke with a disease duration of 1 to 6 months. 3. Aged between 18 and 75 years. Stable vital signs and absence of cardiac conditions. 4. Presence of hemiplegia resulting from the stroke. 5. Brunnstrom Stage of II to III in the affected lower limb, with a sitting balance capacity of at least Grade 2. 6. Muscle tone (hemiplegic side) = Modified Ashworth Scale 1 7.Hemodynamically stable and without severe visual or auditory disorders. 8. No significant cognitive impairment, as defined by the Mini-Mental State Examination (MMSE) score of >=17 (illiterate), >=20 (primary school education), or >=24 (junior high school education or above). 9. Adequate motor imagery ability, indicated by a score of >=40 on the Chinese version of the Kinesthetic and Visual Imagery Questionnaire (KVIQ-10). 10. Able to understand the study procedure and provides written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of epilepsy, bleeding tendency, or severe impairment/failure of major organ functions (e.g., heart, lung, liver, kidney). 2. Presence of intracranial metal implants, cardiac pacemakers, or skull defects. 3. Severe lower limb pain or spasticity that would impede cycling training. 4. Pathologies in or adjacent to the target joints, including but not limited to: pre-existing joint disease, fracture, severe local osteoporosis, severely limited range of motion, or malignancy in the area. 5. Skin breakdown, ulcers, or defects at the intended headwear placement site. 6. Co-morbid other neurological or psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer assessment-lower extremity, FMA-LE; | — |
Secondary
| Measure | Time frame |
|---|---|
| resting state functional connectivity, RSFC;laterality index, LI;co-contraction ratio,CCR;Task-based functional connectivity of brain networks;Root mean square amplitude of lower limb muscle electromyography;Change in Oxyhemoglobin Concentration; | — |
Countries
China
Contacts
Public ContactZheng Wang
Department 1 of Neurological Rehabilitation, Zhejiang Rehabilitation Medical Center(The Affiliated Rehabilitation Hospital of Zhejiang Chinese Medical University)
Outcome results
None listed