Postoperative Delirium
Conditions
Interventions
Treatment group:Take 0.08mg/kg midazolam oral solution before going to bed the night before the operation
Control group:A volume (ml) = body weight (kg) × 0.04 10% glucose solution was taken at bedtime the night before surgery
Sponsors
Third Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. patients undergoing elective hip or knee replacement or revision under general anesthesia; 2. Preoperative Athens Insomnia Scale (AIS) score =6; 3. Age 60-75 years old, ASA physical status I-III; 4. Elderly patients who could cooperate to complete the scale; 5. Consent to participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. were participating in or had participated in other clinical trials in the past three months; 2. Patients underwent more than one operation or emergency operation during this hospitalization due to their condition; 3. body mass index (BMI) > 35 kg/m^2; 4. severe preoperative cognitive impairment, such as Alzheimer's disease or Montreal Cognitive Assessment (MoCA) score < 10. 5. Preoperative delirium or confusion assessment (CAM) was positive; 6. having a history of psychosis or taking antipsychotics, sleep-improving drugs or benzodiazepines; 7. severe respiratory and circulatory diseases such as sleep apnea syndrome; 8. severe liver and kidney damage; 9. Other conditions considered by the attending physician or investigator to be inappropriate for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delirium in the postanesthesia care unit;Postoperative Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality and score;Anxiety score on the day of surgery;Perioperative vital signs;Extubation time and postanesthesia care unit stay time;Pain score; | — |
Countries
China
Contacts
Public ContactWen Ouyang
Third Xiangya Hospital, Central South University
Outcome results
None listed