Bowel Preparation for Colonoscopy in Elderly Patients with Chronic Constipation
Conditions
Interventions
Group A:Calcium Polycarbophil Tablets+ Polyethylene Glycol (PEG)
Group B:Polyethylene Glycol (PEG)
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years, any gender, scheduled for elective colonoscopy; 2. Diagnosis of chronic constipation; 3. Voluntary participation in the study, signed informed consent, and good compliance.
Exclusion criteria
Exclusion criteria: 1. Individuals with contraindications to bowel preparation or colonoscopy; 2. Recent (within 7 days before enrollment) use of medications that may interact with the study drugs, including active vitamin D preparations, calcium supplements, tetracyclines and quinolone antibiotics, proton pump inhibitors, H2 receptor antagonists, or antacids, or use of laxatives (e.g., lactulose, PEG, mannitol, senna, etc.); 3. Presence of colorectal cancer alarm symptoms or signs, such as hematochezia, melena, unexplained anemia or weight loss, abdominal mass, or positive findings on digital rectal examination; 4. Presence of intestinal obstruction, intestinal perforation, acute abdominal pain, or suspected acute abdomen; 5. History of gastrointestinal surgery resulting in significant anatomical alterations (e.g., extensive bowel resection, ostomy, gastrointestinal bypass surgery); 6. Active inflammatory bowel disease, such as ulcerative colitis or Crohn’s disease; 7. Severe dysphagia or gastrointestinal strictures; 8. Severe cardiopulmonary, hepatic, or renal dysfunction, making colonoscopy unsuitable; 9. Electrolyte disturbances; 10. Known allergy or intolerance to calcium polycarbophil, polyethylene glycol electrolyte solution, or any excipients used in this study; 11. Hypercalcemia or a history of conditions predisposing to hypercalcemia; 12. History of kidney stones; 13. Significant cognitive impairment, severe dementia, or psychiatric disorders preventing participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Boston Bowel Preparation Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bowel preparation completion rate;Cleansing score of each colonic segment;Bubble score;Adenoma Detection Rate;Polyp Detection Rate;Gut microbiota indicators;Willingness to repeat colonoscopy;Willingness to repeat the bowel preparation;Tolerance rate of bowel preparation;Adverse Events; | — |
Countries
China
Contacts
Public ContactDekui Zhang
Lanzhou University Second Hospital
Outcome results
None listed