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The Role and Mechanism of circPLCB3 in Reversing Hypertension-Induced Microvascular Rarefaction

The Role and Mechanism of circPLCB3 in Reversing Hypertension-Induced Microvascular Rarefaction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600118769
Enrollment
Unknown
Registered
2026-02-10
Start date
2026-02-24
Completion date
Unknown
Last updated
2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

Healthy control group:None
Hypertension case group:None

Sponsors

PEKING UNIVERSITY SHENZHEN HOSPITAL
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.In this study, the case group consisted of patients with hypertension. The inclusion criteria were based on the diagnostic standards outlined in the 2018 Chinese Guidelines for the Prevention and Treatment of Hypertension: hypertension was diagnosed if, in the absence of antihypertensive medication, three separate clinic blood pressure measurements on different days showed systolic blood pressure =140 mmHg and/or diastolic blood pressure =90 mmHg; 2.or if the patient had a documented history of hypertension and was currently taking antihypertensive medication, even if the current blood pressure was below 140/90 mmHg. The control group comprised healthy individuals, with inclusion criteria being health volunteers recruited during the same period, who had clinic blood pressure <140/90 mmHg, no history of hypertension, and no use of antihypertensive medications.

Exclusion criteria

Exclusion criteria: Patients with secondary hypertension, comorbid malignancies, heart/kidney failure, stroke, autoimmune diseases, or other relevant conditions were excluded.

Design outcomes

Primary

MeasureTime frame
hypertension;

Secondary

MeasureTime frame
Body Mass Index;Age, gender.;

Countries

China

Contacts

Public ContactJikang Shi

PEKING UNIVERSITY SHENZHEN HOSPITAL

jkshi@pkuszh.com+86 755 8392 3109

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 19, 2026