prolonged disorders of consciousness
Conditions
Interventions
Combined Left DLPFC-Cerebellar Stimulation Group:The sequential stimulation targeted the left DLPFC and the cerebellum, using an rTMS protocol at 10 Hz. Each stimulation train lasted 2 seconds, follow
Left DLPFC Stimulation Group:The left DLPFC alone was used as the stimulation target, with the cerebellum serving as the sham stimulation target. The rTMS parameters were as follows: stimulation inten
Sponsors
Jinhua Hospital of TCM Afliated to Zhejiang University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for pDoC as outlined in the Chinese Expert Consensus on the Diagnosis and Treatment of Disorders of Consciousness. 2.Age between 18 and 75 years; 3.Normal cognitive, interpersonal, visual, and auditory functions prior to brain injury; 4.Stable vital signs; 5.Willingness of family members or authorized representatives to participate in the study, with signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Presence of severe complications in systems such as respiratory or circulatory systems, with unstable vital signs; 2.Patients with concomitant status epilepticus; 3.Presence of intracranial infection; 4.Age greater than 75 years or less than 18 years; 5.CT or MRI showing significant cerebral edema; 6.Unwillingness or inability of family members or guardians to cooperate with the treatment, or refusal to sign the informed consent form; 7.Presence of metal foreign bodies in the body, cardiac pacemakers, arterial clips, significant skull defects, unresolved hematomas, or other factors affecting TMS-EEG signal acquisition; 8.Unstable clinical condition or presence of other severe cardiac, pulmonary, hepatic, or renal diseases; 9.Currently receiving other clinical central nervous system intervention therapies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale-Revised; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nociception Coma Scale-Revised;Disability Rating Scale; | — |
Countries
China
Contacts
Public ContactLingyan Wang
Jinhua Hospital of TCM Afliated to Zhejiang University of Traditional Chinese Medicine
Outcome results
None listed