Postoperative Pain
Conditions
Interventions
control group:Intrapleural analgesia with normal saline
Intrapleural analgesia with 0.25% bupivacaine:Intrapleural analgesia with 0.25% bupivacaine
Intrapleural analgesia with 0.125% bupivacaine:Intrapleural analgesia with 0.125% bupivacaine
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective video-assisted thoracoscopic surgery; 2.Age>=18 years; 3.American Society of Anesthesiologists (ASA) physical status classification I–III;
Exclusion criteria
Exclusion criteria: 1.Pregnancy or breastfeeding; 2.History of chronic pain; 3.History of alcohol or opioid dependence; 4.Significant cardiopulmonary dysfunction, including heart failure or severe cardiac conduction abnormalities; 5.Coexisting central nervous system disorders; 6.Hepatic or renal dysfunction; 7.Known hypersensitivity to local anesthetics or opioids; 8.Local infection at or near the planned site of regional anesthesia, or systemic infection; 9.Language impairment or difficulty in communication; 10.Refusal to participate in the study or refusal to use patient-controlled analgesia; 11.Concurrent participation in another clinical trial;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve (AUC) of pain scores during coughing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rescue analgesic consumption;Patient Satisfaction with Pain Management;Plasma bupivacaine concentration;Area under the curve (AUC) of resting pain scores;Serum Inflammatory Markers;Postoperative Opioid Consumption;Quality of Recovery;Adverse Events; | — |
Countries
China
Contacts
Public ContactJi Liu
Shanghai Pulmonary Hospital
Outcome results
None listed