Asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia
Conditions
Interventions
Trail group :Supplement vitamin A, 1800 units/capsule, 2 capsules, po qd*30d.
Sponsors
Children's Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 1 month to under 18 years old; 2. Bone marrow morphologic diagnosis of acute lymphoblastic leukemia; 3. The immune type is acute lymphoblastic leukemia.
Exclusion criteria
Exclusion criteria: 1. Previous history of pancreatitis or other diseases that can cause pancreatitis (hyperlipidemia, hypercholesterolemia, cholelithiasis); 2. Delay of treatment for more than two weeks due to economic interruption; 3. Except for acute pancreatitis without PEG-ASP; 4. Other adverse reactions other than AAP, PEG-ASP changed to L-ASP or Erwinia-ASP chemotherapy; 5. The duration of hospitalization is less than 2 days; 6. Use vitamin A preparation before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of pancreatitis; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of pancreatitis was the rate of elevated blood amylase;Length of stay;28-day ending;Vitamin A level;Asparaginase concentration; | — |
Countries
China
Contacts
Public ContactShaoyan Hu
Children's Hospital of Soochow University
Outcome results
None listed