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Research on the Correlation between Biomarkers such as Metabolites Derived from Gut Microbiota and Heart Failure

Longitudinal and cross-sectional studies on the correlation between biomarkers such as trimethylamine N-oxide, a metabolite derived from the microbiota of Chinese and British patients, and heart failure.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600118743
Enrollment
Unknown
Registered
2026-02-10
Start date
2019-08-02
Completion date
Unknown
Last updated
2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

Observational study:NO

Sponsors

Tongren Hospital Shanghai Jiao Tong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
70 Years to 86 Years

Inclusion criteria

Inclusion criteria: Consecutive patients with age > 18 years admitted for symptoms of new onset or worsening heart failure were enrolled. Objective evidence of cardiac dysfunction with left ventricular ejection fraction of 400 pg/ml was also used as inclusion criteria.

Exclusion criteria

Exclusion criteria: Previous history of cancer or renal dysfunction with Estimated Glomerular Filtration Rate (eGFR )< 15 ml/min/1.73m2, surgical procedure within the previous month, presence of sepsis, acute coronary syndrome in the previous three months, implantable cardiac defibrillator of cardiac resynchronization therapy within the previous four weeks, presence of acute myocarditis or hypertrophic obstructive or constrictive cardiomyopathy, heart transplant recipient or admission for cardiac transplantation or left ventricular assist device implantation were exclusion criteria.

Design outcomes

Primary

MeasureTime frame
trimethylamine-N-oxide;Choline;Acetyl-L-carnitine;L-carnitine;?-butyrobetaine;

Countries

China

Contacts

Public ContactHuiming Sheng

Tongren Hospital Shanghai Jiao Tong University School of Medicine

hmsheng@shsmu.edu.cn+86 189 1718 1019

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 19, 2026