Muscle damage and degeneration
Conditions
Interventions
Myografts transplantation group:Myografts are taken from a healthy area and transplanted to the subcutaneous site of injury and degeneration.
Sponsors
National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation-Binhai Yangshi Orthopedic Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 65 years, regardless of gender. 2. The patient's underlying disease is stable and not in an acute exacerbation phase. 3. The patient has muscle injury and degeneration requiring autologous muscle flap transplantation. 4. Written informed consent has been obtained from the patient, immediate family members, or legal guardians, agreeing to undergo the transplantation procedure.
Exclusion criteria
Exclusion criteria: 1. History of malignant tumor; 2. Coagulation dysfunction or use of anticoagulant drugs; 3. Active infection or immunodeficiency; 4. Severe renal or cardiac dysfunction (eGFR 3 times the upper limit of normal); 6. Local severe skin lesions, or previous history of injection site allergic reactions; 7. Use of muscle growth regulatory drugs (such as testosterone, growth hormone) within the past 6 months. 8. Long-term use of hormones or immunosuppressants, including the application of anti-rejection drugs after organ transplantation. 9. Other exclusion factors: participation in other interventional clinical trials (excluding observational studies). 10. The investigator believes that there are other medical or ethical factors that make the subject ineligible for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Basic vital sign monitoring;Local adverse reactions;Evaluation of graft survival;Inflammation and immune status;Liver enzyme indicators;Muscle mass;Muscle thickness;Detection of muscle secreted muscle factors; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone density assessment;Blood lipid profile test;Evaluation of Blood Glucose and Insulin Resistance;Energy consumption monitoring;Fat content assessment; | — |
Countries
China
Contacts
Public ContactPengbin Yin
National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation-Binhai Yangshi Orthopedic Hospital
Outcome results
None listed