depressive with cognitive impairment
Conditions
Interventions
Traditional TBS Group:Left DLPFC:iTBS
Right DLPFC:cTBS
Individualized TBS group:Left DLPFC:iTBS
Parietal lobe target :iTBS
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years old; 2. Meet the diagnostic criteria for depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 3. Hamilton Depression Scale 17-item version (HAMD-17) score >= 17 points; 4. If the medication has never been taken at the time of enrollment, the medication will not be added during,If antidepressants have been taken in the past, drug washout is required for 4 weeks, the treatment period, If you are taking medication, take medication regularly for at least 4 weeks, and the medication remains unchanged during treatment; 5. Be able to cooperate with clinical assessment, magnetic resonance scanning, near-infrared brain function imaging and neuromodulation; 6. Patients voluntarily participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Current or previous diagnosis of bipolar disorder, schizophrenia or other psychotic disorders, schizoaffective disorder, autism or autism spectrum disorder, etc. 2. Neurological diseases such as craniocerebral organic diseases, cranial trauma, refractory epilepsy, and dementia; 3. Patients with serious physical diseases who are not suitable for neuromodulation therapy as judged by the investigator; 4. History of suicide attempt within 3 months; 5. History of substance dependence or substance abuse; 6. Other contraindications to neuromodulation or near-infrared brain function imaging or MRI; 7. Women who are pregnant or are trying to conceive recently.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale, HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sheehan Disability Scale;Self-rating depression scale;Clinical Global Impressions- Improvement;CANTAB-PRM;Self-Rating Anxiety Scale;Wechsler Memory Scale;CANTAB-SSP;Stroop task: Color-word interference effect time;Hamilton Anxiety Scale, HAMA;Columbia-Suicide Severity Rating Scale, C-SSRS ;Pittsburgh sleep quality index, PSQI ;CANTAB-SWM; | — |
Countries
China
Contacts
Public ContactBin Li
West China Hospital of Sichuan University
Outcome results
None listed