Perioperative Neurocognitive Disorders (PND)
Conditions
Interventions
PND group ang NPND group:None
Sponsors
The Second Affiliated Hospital of Jiaxing University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=65 years old; 2. American Society of Anesthesiologists (ASA) grade II - III; 3. Estimated operation time >=2 hours; 4.Total hip arthroplasty under general anesthesia; 5. No cognitive dysfunction before the operation; 6. The patient was informed of this study and signed the informed consent form, voluntarily cooperating with this research.
Exclusion criteria
Exclusion criteria: 1.Other neurological diseases that cause cognitive impairment: such as brain tumors, brain trauma, Parkinson's disease, brain tumors, epilepsy, etc; 2. Patients with mental disorders, those who are unable to cooperate with the examination, and those who refuse the examination; 3. Severe periodontitis, oral malignant tumors; 4. Has a history of periodontal treatment within 3 months; 5. There is obvious acute infection in the oral cavity or other parts of the body; 6. Antibiotics or probiotics were used one month before the operation; 7. Combined with severe diseases of the heart, lungs, liver, kidneys and other systems; 8. Patients undergoing emergency surgery or secondary surgery; 9. Patients transferred to the ICU after surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary microbiome (16S rRNA sequencing) analysis results; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Inflammatory Cytokine Profile Test Results;MMSE and MOCA scores; | — |
Countries
China
Contacts
Public ContactZhou Hongmei
The Second Affiliated Hospital of Jiaxing University
Outcome results
None listed