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Temporal Interferometric Neuromodulation Targeting the Amygdala for Aggression in Alcohol Use Disorder Patients Exploration of the Efficacy and Safety of the Behaviors

Temporal Interferometric Neuromodulation Targeting the Amygdala for Aggression in Alcohol Use Disorder Patients Exploration of the Efficacy and Safety of the Behaviors

Status
Unknown
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600118700
Enrollment
Unknown
Registered
2026-02-10
Start date
2026-02-11
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with alcohol use disorder

Interventions

Sham group :The current intensity is 2mA, with a duration of 1 Interventi minute (rising for 30 seconds and falling for 30 son: econds) to simulate a real-life stimulation experience, lasting for 30
Real group:The stimulation frequency is an envelope frequen Interventi cy of 10Hz, with a treatment duration of 10 days, a current intensity of 2mA, and a duration of 30 minutes.

Sponsors

Anhui Province Veterans Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Meets the diagnostic criteria for alcohol use disorder as stipulated in the "Diagnostic and Statistical Manual of Mental Disorders (5th Edition)"; 2. Revised Manifesto of Aggressive Behavior Scale (MOAS) score = 4 points; 3. Age 18-65 years old, male; 4. Voluntary participation and signing a written informed consent form; 5. Possessing the visual and cognitive abilities required to complete all neuropsychological tests and magnetic resonance imaging examinations; 6. No severe or unstable physical diseases; 7. No contraindications for magnetic resonance imaging (such as no pacemaker, metal implants, etc. in the body).

Exclusion criteria

Exclusion criteria: 1. Suffering from other major mental disorders (such as schizophrenia, bipolar disorder, antisocial personality disorder); 2. Having a history of brain injury, intracranial surgery or epilepsy; 3. Having abused or been dependent on other psychoactive substances other than alcohol within the last 3 months; 4. Having received modified electroconvulsive therapy within the last 3 months; 5. Participating in other clinical intervention trials simultaneously.

Design outcomes

Primary

MeasureTime frame
Modified Overt Aggression Scale, MOAS; ?Impulsive/Premeditated Aggression Scale (IPAS)?;Barratt Impulsiveness Scale Version 11, BIS-11;State-Trait Anger Expression Inventory-2, STAXI-2;Toronto Alexithymia Scale-20, TCDS-20;Penn Alcohol Craving Scale, PACS;Visual Analogue Mood Scale, VAMS;

Secondary

MeasureTime frame
Adverse Questionnaire ;

Countries

China

Contacts

Public ContactChangping Zhai

Anhui Veterans' Hospital

13956361637@qq.com+86 139 5636 1637

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026