Knee osteoarthritis
Conditions
Interventions
Experimental group:Vagus nerve stimulation was applied 30 minutes after breakfast and 30 minutes after dinner at 25 Hz, 250 µs, with a current intensity of 0.25 mA to 2.0 mA. Each session lasted 30 mi
Control group:Vagus nerve stimulation was performed 30 minutes after breakfast and 30 minutes after dinner at 25 Hz, 250 µs, with a current intensity of 0.25 mA–2.0 mA, each session lasting 30 minutes
Sponsors
The Four Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: Aged 65-85, with normal heart, liver, and kidney function, normal consciousness, normal coagulation function, meeting the diagnostic criteria for knee osteoarthritis.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of mental illness, neurological disorders, psychological disorders, allergy to local anesthetics, inability to communicate normally, or those taking antidepressants or anti-anxiety medications; 2.Patients who do not meet the diagnostic criteria for knee osteoarthritis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of VAS=0 to VAS>=4 after 7 days of treatment in the two groups of patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores before nerve block (T0), on the third day of treatment (T1), on the fifth day of treatment (T2), one week after discharge (T3), four weeks after discharge (T4), and eight weeks after block (T5);Pittsburgh Sleep Quality Index;Total amount of tramadol taken during treatment;Anxiety Scale Score (S-AI);Adverse reactions: nausea, dizziness, etc.; | — |
Countries
China
Contacts
Public ContactWang Yan
The Four Affiliated Hospital of Anhui Medical University
Outcome results
None listed