Hypoxia with intravenous anesthesia.
Conditions
Interventions
Group O:Intravenous injection of 0.03mg/kg of oxypertine
Group S:Sufentanil 0.15 µg/kg, intravenous injection
Sponsors
Yantai Affiliated Hospital of Binzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years; 2. ASA class I-III; 3. Ability to comprehend and voluntarily provide informed consent (signed by participant or legal guardian).
Exclusion criteria
Exclusion criteria: 1. Presence of clear symptoms or signs of respiratory tract infection within the last two weeks. 2. Room air oxygen saturation (SpO2) 1 hour. 4. Coagulation dysfunction or platelet count = 450 ms (corrected by Fridericia's formula), or exercise tolerance < 4 METs. 6. History of postoperative nausea and vomiting (PONV). 7. Known allergy to eggs, soy products, opioids, opioid antagonists, propofol, or related agents. 8. Participation in another drug clinical trial as a subject within the past 3 months. 9. History or presence of conditions such as traumatic brain injury, potential for seizures, myoclonus, intracranial hypertension, cerebral aneurysm, or cerebrovascular accident. 10. History of psychiatric or neurological disorders, including schizophrenia, intellectual disability, mania, psychosis, long-term use of psychotropic medications, opioid abuse, alcohol abuse (specified by duration and quantity), or cognitive dysfunction. 11. Emergency surgery. 12. Pregnancy or lactation. 13. Foreseen difficult airway or planned tracheal intubation or laryngeal mask airway use. 14.Patients considered by the investigator to be hemodynamically unstable, at high risk of reflux and aspiration, or otherwise unsuitable for participation in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypoxia (defined as 75% <= SpO2 <= 89%, lasting for <60 seconds) during hysteroscopic procedures.; | — |
Secondary
| Measure | Time frame |
|---|---|
| the lowest SpO2;Incidence of subclinical respiratory depression(90% 60 seconds) during hysteroscopy treatment.;Adverse events related to both anesthesia/sedation and opioid analgesia; | — |
Countries
China
Contacts
Public ContactLi Wei
Yantai Affiliated Hospital of Binzhou Medical University
Outcome results
None listed