Degenerative diseases of the lumbar spine
Conditions
Interventions
Experimental group:Postoperatively, take 60mg of etoricoxib tablets orally once daily (qd) plus 3ml of paracetamol drops three times daily (tid).
Control group:Postoperatively, take 60mg of etoricoxib tablets orally once daily.
Sponsors
Sichuan University West China Tianfu Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The patient is diagnosed with lumbar degenerative diseases (such as lumbar spondylolisthesis, lumbar spinal stenosis, massive lumbar intervertebral disc protrusion), and is planned to undergo elective, single-segment, initial transforaminal lumbar interbody fusion surgery; 2. The patient is aged between 18 and 75 years; 3. American Society of Anesthesiologists classification: I-III grade; 4. The patient is conscious, has no communication, can understand the visual analogue pain rating method, and can cooperate to complete the research-related questionnaires and evaluations; 5. The patient voluntarily participates in this study and has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. The patient has a known history of allergy or contraindication to etoricoxib, acetaminophen, or other non-steroidal anti-inflammatory drugs; 2. The patient has been using opioid analgesics for a long time (defined as continuous use for more than 3 months) before the surgery; 3. The patient has significant organ dysfunction (severe liver dysfunction, renal dysfunction); 4. The patient currently or within the past 6 months has a history of active gastrointestinal ulcers or bleeding; 5. The patient has a clear abnormal coagulation function disorder or is using anticoagulant/antiplatelet drugs such as warfarin, clopidogrel, etc.; 6. The patient has a history of epilepsy, dementia, schizophrenia or other severe mental disorders, and is unable to cooperate with the postoperative analgesia assessment; 7. There is a clear history of alcohol or drug abuse; 8. The patient is a pregnant woman, a lactating woman, or plans to get pregnant within the next 3 months; 9. The patient is concurrently participating in other clinical trials that may affect the postoperative pain assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total consumption of opioid medications within 72 hours post-surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of first use of rescue analgesic medication;Visual Analogue Scale (VAS) Pain Score;Postoperative hospital stay duration; | — |
Countries
China
Contacts
Public ContactLiu Limin
Sichuan University West China Hospital / Sichuan University West China Tianfu Hospital
Outcome results
None listed