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Development of a nomogram model for predicting biochemical recurrence risk after radical prostatectomy based on the fusion of imaging-based omics and clinical pathological features

Development of a nomogram model for predicting biochemical recurrence risk after radical prostatectomy based on the fusion of imaging-based omics and clinical pathological features

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600118661
Enrollment
Unknown
Registered
2026-02-09
Start date
2026-02-09
Completion date
Unknown
Last updated
2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate cancer

Interventions

Observation group:None

Sponsors

Lishui Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1. Received radical prostatectomy (RP) at this hospital between 2021-2024 and completed a complete mpMRI examination before surgery (must include T2WI and ADC sequences); 2. Postoperative pathology report complete, including pT stage, ISUP grade, margin status, and lymph node metastasis status; 3. At least 2 years of regular PSA follow-up (every 3-6 months), able to clearly identify biochemical recurrence (BCR) events (defined as two consecutive postoperative PSA levels =0.2 ng/mL, with the recurrence date being the date the first PSA value >0.20 ng/mL was recorded;for patients without BCR, BCRFS is calculated from the RP date to the date BCR was confirmed or the most recent follow-up date); 4.Complete clinical information (age, preoperative PSA, postoperative PSA at 6 weeks, volume, BMI, etc.), postoperative follow-up information (every 3 months for the first 2 years, every 6 months for the third and fourth years, and annually thereafter, with PSA measured at each follow-up).

Exclusion criteria

Exclusion criteria: 1. Has received any form of prostate cancer-related treatment before surgery (hormonal, radiation, chemotherapy); 2.MRI image quality does not meet the standard (severe motion artifacts, missing sequences, or insufficient resolution); 3. Pathology report missing or ISUP grade cannot be confirmed; 4. Patients lost to follow-up, missing key PSA data, or with unclear time of death.

Design outcomes

Primary

MeasureTime frame
Prostate-specific antigen;Discriminability;Clinical practicality;

Countries

China

Contacts

Public ContactJiafeng Ding

Lishui Central Hospital

260747937@qq.com+86 578 228 5318

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 19, 2026