Postoperative Neurocognitive Disorder(PND)
Conditions
Interventions
Early postoperative prediction of high-risk treatment group for POD:Early postoperative sequential treatment with traditional Chinese and Western medicine
Early postoperative prediction of high-risk control group for POD:none
Preoperative prediction of high-risk treatment group for POD:Preoperative sequential treatment plan combining traditional Chinese and Western medicine
observation group:none
Preoperative Prediction of High-Risk Control Group for POD:none
Sponsors
The Second Hospital of Jiaxing
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Scheduled for elective total hip or knee arthroplasty under general anesthesia. 2.Age >= 65 years. 3.ASA physical status I–III. 4.BMI 3 days.
Exclusion criteria
Exclusion criteria: 1.The score of the Mini Mental State Examination (MMSE) is lower than the corresponding educational level reference value (<16 points for individuals with secondary education); 2.Combining severe brain disorders, mental illnesses, or other cognitive dysfunction disorders; 3.Patients who use drugs known to affect cognitive function before or after surgery; 4.After surgery, it is necessary to continue treatment in the ICU; 5.During the study period, patients were unable to complete follow-up or data recording for any reason;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral blood levels of CXCL10;Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative indicators;age;Postoperative safety indicators;Hamilton Depression Rating Scale (HAM-D) score;Fried Frailty Phenotype Score;Educational level;Postoperative recovery time;Intraoperative sedative drug dosage;Intraoperative hypotension occurrence;Peripheral blood levels of BDNF;The ASA classification;Intraoperative highest and lowest mean arterial pressure;Postoperative safety indicators;Richards-Campbell Sleep Questionnaire (RCSQ) score;Intraoperative urine output;sex;Intraoperative lowest oxygen saturation value;Age-adjusted Charlson Comorbidity Index;Montreal Cognitive Assessment (MoCA) score;Hamilton Anxiety Rating Scale (HAM-A) score;Mini-Mental State Examination (MMSE) score;Body Mass Index (BMI);electrolyte imbalance;Intraoperative transfusion status;Hearing;Body temperature;Instrumental Activities of Daily Living (IADL);Whether there is hypoalbuminemia;Occurrence of drug-related adverse reactions;The Numeric Rating Scale (NRS);Underlying disease;Intraoperative dosage of vasopressor drugs;Surgical type;Intraoperative catheterization status;Intraoperative fluid intake;Intraoperative analgesic drug dosage;Surgical duration; | — |
Countries
China
Contacts
Public ContactLi Hu
The Second Hospital of Jiaxing
Outcome results
None listed