Alzheimers disease,Dementia
Conditions
Interventions
Study Group:(1) Both groups routinely used cholinesterase inhibitors. Both groups could administer low-dose antipsychotic medications such as risperidone or quetiapine based on patients' psychotic and
Control Group: Both groups routinely used cholinesterase inhibitors. Both groups could administer low-dose antipsychotic medications such as risperidone or quetiapine based on patients' psychotic and
Sponsors
Chongqing Mental Health Center
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Healthy male and female subjects aged 60 to 85 years (including 60 and 85 years); 2. Meet the clinical description and diagnostic criteria for Alzheimer's disease and vascular dementia as defined in the International Classification of Diseases, Tenth Revision (ICD-10); 3. Mini-Mental State Examination (MMSE) score between 10 and 24; 4. All patients exhibit significant neuropsychiatric symptoms, with a BEHAVE-AD score =8 points. 5. No significant hearing or visual impairment; capable of simple communication and willing to undergo assessment after thorough explanation. 6. Family members fully understand the trial and provide signed informed consent prior to screening; 7. No severe physical illnesses.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to cholinesterase inhibitors or antipsychotic medications; 2. Patients who request discontinuation due to adverse events; 3. Patients who withdraw informed consent; 4. Patients whose treatment is interrupted after enrollment due to non-drug-related causes such as severe physical illness; 5. Patients deemed ineligible for enrollment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer’s disease assessment scale, ADAS-cog; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life–Alzheimer’s Disease ;Activity of Daily Living Scale;Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD);Clinical Global Impression (CGI) Scale;Mini-Mental State Examination (MMSE);oxyhemoglobin;deoxy hemoglobin; | — |
Countries
China
Contacts
Public ContactZhao Xinmin
Chongqing Mental Health Center
Outcome results
None listed