Major Depressive Disorder
Conditions
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. be 18-60 years of age, male or female, right-handed. 2. meets the DSM-5 diagnosis of current or recurrent episodes of major depressive disorder. 3. structured diagnostic confirmation using the MINI; additional SCID-5 review if diagnostic uncertainty exists or if further exclusion of bipolar/psychotic disorders is required. 4. duration of the current depressive episode >=4 weeks. 5. 17-item Hamilton Depression Scale >=14 points. 6. presence of subjective cognitive symptoms at the time of PDQ-D scoring. 7. voluntary participation in the study and written informed consent.
Exclusion criteria
Exclusion criteria: 1. other significant mental disorder: bipolar disorder, schizophrenia or other psychotic disorder, autism spectrum disorder, severe neurocognitive disorder, intellectual disability; or current obsessive-compulsive disorder (OCD), PTSD, eating disorders, or anxiety disorders that significantly affect functioning. 2. recent history of strong interventions: ECT, ketamine/eketamine, rTMS/tDCS in the last 4 weeks. 3. suicidal risk: suicide attempt in the last 12 months; or current definite suicidal plan, clinically assessed as inappropriate for participation. 4. neurological disorders: epilepsy, stroke, loss of consciousness following craniocerebral trauma, intracranial tumour, demyelinating disease or other definite organic brain lesions. 5. severe or unstable somatic disease: uncontrolled cardiovascular disease, severe hepatic or renal insufficiency, uncontrolled endocrine disease, etc., which in the judgement of the investigator may increase the risk of the study. 6. tTIS/MRI contraindications: metal implants in vivo or other MRI contraindications; presence of severe skin lesions in the area of scalp irritation; severe claustrophobia. 7. Pregnant or lactating females. 8. Those taking cognitive-impairing medications (e.g., anticholinesterases, psychostimulants, and other anti-dementia medications) within 4 weeks prior to enrolment that cannot be discontinued upon assessment. 9. Previous history of alcohol or tobacco abuse. 10. Other conditions that, in the judgement of the investigator, make enrolment inappropriate. 11. Other diseases affecting cognitive function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression Perceptual Deficits Questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety and Depression Scale;Selective reaction time identification task;Numeric Symbol Substitution Test; | — |
Countries
China
Contacts
Public ContactZhu Zhou
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed